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End Of A Long Journey: What to Do When You Reach Your Destination



Ahead of the 75th anniversaries of the bombings on August 6th and 9th, ICAN and the 1945 project are releasing a new resource to take you through the journey of the hibakusha, from the bombings in 1945 through decades of advocacy to the adoption of the Treaty on the Prohibition of Nuclear Weapons.




End Of A Long Journey




Hearing the testimony of the hibakusha, their memories of the day of the bombings and their ensuing long-term impact, is essential to understand nuclear weapons for what they truly are. Learning about the journey of the hibakusha not only to survive the unprecedented trauma of the nuclear attacks but to also advocate for the elimination of nuclear weapons, from collecting millions of signatures for petitions to adopting an international treaty, has inspired nuclear abolition activists for decades.


For Robert and Julie, the reality soon become undeniable as they alternated between staying in motels when they could and camping in their two vehicles. They quickly depleted their cash along with any financial help they could get from family. They needed to seek help to get housed before they could land jobs and take other next steps.


Cholera, a diarrheal disease caused by Vibrio cholerae (V. cholerae) O139 and O1 strains, remains a public health problem. The existing World Health Organization (WHO)-licenced, killed, multiple-dose oral cholera vaccines demand 'cold-chain supply' at 2 C-8 C. Therefore, a live, single-dose, cold-chain-free vaccine would relieve significant bottlenecks and costs of cholera vaccination campaigns. Our cholera vaccine development journey started in 2000 at Universiti Sains Malaysia with isolation of the hemA gene from V. cholerae, followed by development of a gene mutant vaccine candidate VCUSM2 against V. cholerae O139 in 2006. In 2010, VCUSM2 reactogenicity was reduced by replacing its two wild-type ctxA gene copies with mutated ctxA to produce strain VCUSM14. Introducing the hemA gene into VCUSM14 created VCUSM14P, a strain with the 5-aminolaevulinic acid (ALA) prototrophic trait and excellent colonisation and immunological properties (100% protection to wild-type challenged rabbits). It was further refined in Asian Institute of Medicine, Science and Technology (AIMST University), with completion of single- and repeated-dose toxicity evaluations in 2019 in Sprague Dawley (SD) rats, followed by development of a novel cold-chain-free VCUSM14P formulation in 2020. VCUSM14P is unique for its intact cholera toxin B, a known mucosal adjuvant. The built-in adjuvant makes VCUSM14P an ideal vaccine delivery platform for emerging diseases (e.g. severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] and tuberculosis). Our vaccine formulation mimics natural infection, remains non-reactogenic and immunogenic in vivo, and protects against infection and disease. It will also cost less and be less cumbersome to distribute due to its stability at room temperature. These features could revolutionise the outreach of this and other vaccines to meet global immunisation programmes, particularly in low-resourced areas. The next stage of our journey will be meeting the requisite regulatory requirements to produce the vaccine for rollout to countries where it is most needed.


GRANT: Opportunity has been on a long trek across the Meridiani Planum plains. It's about 12 kilometers of crow flies, but because we had to go around a bunch of ripples that are sort of like little sand dunes, we kind of took a scenic route of 19 kilometers. And the science team is just elated because we've reached this terrain that is obviously different than anything that we've been on before.


At more than 2,300 miles (3,700 km), the Missouri River is the longest river in North America. It cascades over several large falls before emptying into the Mississippi River north of St. Louis, Missouri. The journey along the Mississippi River from its confluence with the Missouri River to its mouth at the Gulf of Mexico is about 1,200 miles (about 1,900 kilometers) long. In total, some of the water that erupted from Old Faithful geyser traveled for more than 3,700 miles (almost 6,000 kilometers) before entering the Gulf of Mexico. This is more than 1,000 miles longer than the flight distance between New York and Los Angeles.


The presence of the Continental Divide in the park can make for some curious features. Isa Lake is located directly astride the Continental Divide at Craig Pass along the road that connects Old Faithful and West Thumb Geyser Basin on the shore of Yellowstone Lake. Isa Lake is one of the few natural lakes in the world which drains to two different oceans. The east side of Isa Lake drains into the Lewis River and after a very long journey, into the Pacific Ocean. The west side of the lake drains into the Firehole River and ultimately to the Gulf of Mexico.


So, the next time you happen to see Old Faithful Geyser erupting, take a moment to appreciate the long journey that the water is beginning. The waters of Yellowstone go on spectacular trips, ending in both oceans and traversing thousands of miles along the way!


I spent weeks talking to migrants like Ariel who had reached this point of their journey during my sociological field research in two northern Mexican towns in Sonora state: Altar, a village of about 8,000; and nearby Caborca, a sizable city of about 100,000. Many, but not all, of them were Central American.


In the maps that migrants make in workshops organized by the psychologist of the Community Center for Attention to Migrants and the Needy, Altar appears both as the end of a long road and as the beginning of a new one to the United States.


Of course, some problems are still left open, particularly Mary's morphine addiction, which we see at its worst in this act. Mary can no longer even see the real world as she falls into a hallucinogenic state in which she thinks she is back in her convent. It is very clear now that she takes her morphine to escape the reality of the present and to bring herself back to a time when her life was open and full of hope. Her closing speech ends the play with the expectation that the situation will not get better overnight. Instead, the play ends leaving the audience with the sense that the day is not particularly special; the events of this August day are likely to repeated by the family which is stuck in an endless cycle of broken dreams, conflicts and drugs.


"In this particular situation, the restaurant is located on the major commercial corridor of the Sarasota market with direct proximity and accessibility to where our customer resides and works, along with nearby hotels to serve Sarasota visitors," Finley said.


Emmy-award winning actor Brian Cox will star as James Tyrone in a new production of Eugene O'Neill's magnum opus Long Day's Journey into Night, widely considered one of the greatest American plays of the 20th Century. This new production, which will open in the West End, will be directed by Jeremy Herrin.Brian Cox says: "It has long been an ambition of mine to play Eugene O'Neill's flawed patriarch James Tyrone, and I'm delighted to have the opportunity to do so on a West End stage. I'm a great admirer of Jeremy Herrin's work and I am looking forward to us delving into O'Neill's masterpiece together."Jeremy Herrin says: "It's the privilege of a lifetime to direct one of our finest actors in one of the greatest plays ever written. The peerless Brian Cox as James Tyrone is a match for the ages, and a wonderful opportunity to create a deeply moving and cathartic piece of the theatre."


Enjoy the Great Outdoors & the Long Lake Region Long Lake is the longest lake in the area, and offers prime opportunities for swimming, boating, paddling, and fishing. For those into hiking, Buttermilk Falls, Owls Head Mountain, and the Northville-Lake Placid Trail are less than 10 minutes away, and Goodnow Mountain is about 15 minutes from Journey's End.


In the short time I spent with these characters, I feel like I only scratched the surface of who they were and how they would grow to care for each other along the way. That scratch at least was deep enough to finally gain an understanding of how their skills, interests, and specialties would determine if we could complete odd jobs as we traveled through space.


The theme is repeated in the third and fourth book with another genius who invents means of locomotion: wagons and boats driven by oar or sail. The men of the North, ready now to listen to the old call to the summer lands, begin the long journey proper.


The later books describing the journey take us down to historical times: we see the Cimbri marching on Rome and the Vikings' raids. But the story does not end until Columbus realizes that dream of a tropical paradise which is the leading idea of the book.


Solving the problem would be worth hundreds of millions of dollars, but the company needed a whole new way of thinking about and managing its service operations to identify and reimagine the customer-experience journeys that mattered most.


So how should companies tackle this issue? In our experience, six actions are critical to managing customer-experience journeys (articles elsewhere in this volume explore several of these topics in depth):


Journeys are often longer than you think. For example, the onboarding journey in the cable industry can extend through two or three billing cycles. (Most calls in the first few months are actually onboarding-related issues and inquiries.)


Moreover, the companies that perform best on journeys have a more distinct competitive advantage than those that excel at touchpoints; in one of the industries we surveyed, the gap on customer satisfaction between the top- and bottom-quartile companies on journey performance was 50 percent wider than the gap between the top- and bottom-quartile companies on touchpoint performance. Put simply, most companies perform fairly well on touchpoints, but distinctive performance on journeys can set a company apart. 2ff7e9595c


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